Abstract Background The regulatory roles of long non-coding RNA (lncRNA) CRNDE in temozolomide (TMZ) chemoresistance to glioblastoma multiforme (GBM) are still poorly understood.Therefore, the function, characteristics, and possible mechanism of CRNDE in TMZ-induced chemoresistance to GBM were explored.Methods Firstly, the expression level of CRNDE
At present, the preventive effect of ischemic stroke is not ideal, and the preventive drugs are limited.Danshen, the dried root of Salvia miltiorrhiza Bge, is a common medicinal herb in Traditional Chinese Medicine, which has been used for the treatment of cardiovascular diseases for many years.Phenolic Acids extracted from danshen, which showed mu
The globus pallidus occupies a critical position in the indirect pathway of the basal ganglia motor control system.Hyperpolarization-activated cyclic-nucleotide gated (HCN) channels play an important role in the modulation of neuronal excitability.In vivo extracellular single unit recording, behavioral test and immunohistochemistry were performed t
Phosphatidylglycerol is a crucial phospholipid found ubiquitously in biological membranes of prokaryotic and eukaryotic cells.The phosphatidylglycerol phosphate (PGP) synthase (PgsA), a membrane-embedded enzyme, catalyzes the primary reaction of phosphatidylglycerol biosynthesis.Mutations in pgsA frequently correlate with daptomycin resistance in S